Are Resveratrol and Other Drugs Being Researched for Anti-Aging Properties in Humans?
Question by Kevin7: are resveratrol and other drugs being researched for anti-aging properties in humans?
Best answer:
Answer by Ted H
May 1, 2012….Resveratrol, the plant compound found in red wine and reputed to have anti-aging effects, including protection against cancer and diabetes, has just had a “told-you-so” moment.
Resveratrol’s discoverer, the embattled Harvard professor who hopes it will point the way to new anti-aging drugs, long argued that the phytonutrient worked its magic by “turning on” the SIRT1 gene. The SIRT1 gene, one of a family of genes, the Sirtuins, is believed to control the good function and longevity of cells and, in turn, of their host.
But Harvard professor David Sinclair’s critics argued, in effect, that the SIRT1 gene was not the lock for which Resveratrol was the key. Rather, they said, Resveratrol had its effect by a somewhat less magical route: it turned up the activity of an important metabolic sensor called the AMP-activated protein kinase. Some even argued that outside the test tube, Resveratrol loses its anti-aging power of cells completely.
By breeding a mouse that can live without the SIRT1 gene, Sinclair showed otherwise. His study is published in the journal Cell Metabolism. Mice who lacked the SIRT1 gene got no benefit from Resveratrol. But those that had the gene responded to Resveratrol with improved vascular and metabolic function, reduced inflammation and overall, cells that use fuel and clean up waste more efficiently. Even chubby mice responded to Resveratrol with improved function.
The discovery of how Resveratrol works should “allow the development of more potent and specific molecules”–drugs that could prevent diseases of aging more powerfully and with less risk of side effects than Resveratrol.
Speaking of side effects, the study also found that like any powerful agent, Resveratrol could have toxic effects at too-high doses. At high doses, researchers found, Resveratrol induced changes in cells and their activity that made them vulnerable to early death and inefficient fuel use. For the growing numbers of people considering Resveratrol, that should serve as a warning that more is not always better.
http://www.latimes.com/health/boostershots/la-heb-resveratrol-20120501,0,7425264.story
13 September, 2010….A Russian scientist says he has beaten the problem of aging and in just a few years the medicine that stops it will go on sale. Professor Vladimir Skulachev says he managed to find an anti-oxidant that stops the gradual deterioration of health caused by age. It looks complicated and it certainly is. For Vladimir Skulachev it is almost a life’s work. Two more years of testing and the doctor thinks he will have finally cracked the enigma of aging. Apparently it’s all about how oxygen reacts in the body.
“99% of the time oxygen turns into harmless water, but there’s that one percent that turns into a super-oxide that later turns into very poisonous elements,” Vladimir Skulachev, Professor of Bioenergetics, reveals. “So the task was to find an anti-oxidant that stops that process.” And hence, according to the professor, it would also stop people from getting old.
He has been working to prefect his treatment for more than 40 years. The difficult part of the process has been to try and prevent any side-effects, he notes.
Colleagues around the world think Dr Skulachev is on to something. The compound has already undergone animal testing and the results appear promising. Rats that have been given the drug are much more lively than those not treated. After success with eye drops in animals, the inventor tried the medicine on his own cataract. Six months later, his physician told him his cataract was gone.
Thousands are queuing to take part in the clinical trials, which have just begun. But it will be a few years before Dr Skulachev’s discovery reaches the shelves of an average pharmacy.
http://rt.com/news/ageing-problem-medicine-skulachev/
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